Global Bioprocessing Summit & Exhibition 2025
Global Bioprocessing Summit & Exhibition - Ypso Facto
Global Bioprocessing Summit & Exhibition. Berlin, May 10-12 2023 (Booth 1)
Ypso-Facto is attending the Global Bioprocessing Summit & Exhibition in Berlin from 10-12 May, 2023.
During this event, world-class technology leaders, scientists, and engineers from the pharmaceutical, biotech, and pharma supply industries will come together to discuss commercial progress and large-scale successful bioprocessing.
Register for the conference and Chris McKay's talk on our project Purification by Ion Exchange Chromatography: Process Understanding, Modelling and Simulation applied to the Oligonucleotide Bepirovirsen
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increased demand for their manufacture. Typically produced by solid phase synthesis and then purified by ion exchange or reverse-phase chromatography, solid process understanding is vital to make the most of manufacturing capacity. To achieve an optimized process, many operating parameters need to be investigated to determine their optimal values (e.g. quantity of crude injected, wash duration, gradient slope, pH, flow rate, column dimensions, etc). A typical objective is maximizing yield for a given purity constraint, but also minimizing raw materials consumption and waste generation. Testing all possible combinations experimentally is not always possible due to material costs or human resource constraints, therefore we have investigated the use of predictive mechanistic simulation to aid process optimisation.
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Berlin - Berlin, Berlin, Germany Berlin - Berlin, Berlin, Germany
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